Anti-heparin-platelet factor 4 antibodies after cardiopulmonary bypass: role of HLA expression.
نویسندگان
چکیده
منابع مشابه
Antibodies to platelet factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin : clinical implications for heparin-induced thrombocytopenia.
BACKGROUND Cardiopulmonary bypass (CPB) induces platelet activation with release of platelet factor 4 (PF4), and patients are exposed to high doses of heparin (H). We investigated whether this contributes to the development of antibodies to H-PF4 and heparin-induced thrombocytopenia (HIT). METHODS AND RESULTS CPB was performed with unfractionated heparin (UFH) in 328 patients. After surgery, ...
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عنوان ژورنال:
- Haematologica
دوره 86 3 شماره
صفحات -
تاریخ انتشار 2001